Molecular biology genes to proteins pdf

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The central dogma of molecular biology is an molecular biology genes to proteins pdf of the flow of genetic information within a biological system. In more detail, the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible. Information means here the precise determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein.


The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that such information cannot be transferred back from protein to either protein or nucleic acid. A second version of the Central Dogma is popular but incorrect. While the dogma, as originally stated by Crick, remains valid today, Watson’s version does not.

The dogma is a framework for understanding the transfer of sequence information between information-carrying biopolymers, in the most common or general case, in living organisms. 9 conceivable direct transfers of information that can occur between these. DNA template without the use of mRNA.

The unknown transfers describe: a protein being copied from a protein, synthesis of RNA using the primary structure of a protein as a template, and DNA synthesis using the primary structure of a protein as a template – these are not thought to naturally occur. The sequence of their monomers effectively encodes information.